afoxolaner dosage for dogs

This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Each chewable tablet contains: Active substance: NexGard Afoxolaner (mg) chewable tablets for dogs 2–4 kg 11.3 chewable tablets for dogs >4–10 kg 28.3 chewable tablets for dogs >10–25 kg 68 chewable tablets for dogs >25–50 kg … Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. In some countries, this medicine may only be approved for veterinary use. At 72 hours post-infestation, NexGard demonstrated >97% effectiveness against Amblyomma americanum for 30 days. Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to inhibit insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. To optimize drug potency and pharmac… The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. Keep this and all drugs out of the reach of children. There were no clinically-relevant effects related to treatment on physical examination, body weight, food consumption, clinical pathology (hematology, clinical chemistries, or coagulation tests), gross pathology, histopathology or organ weights. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. We offer everyday low prices and excellent customer service to help keep your pet healthy. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product. Color Pets Weight (lb) Weight (kg) Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. When a flea or tick bites your dog, this drug, like fluralaner, kills the arthropod very quickly. In a separate well-controlled laboratory study, NexGard demonstrated 100% effectiveness against adult fleas 24 hours post-infestation for 35 days, and was ≥93% effective at 12 hours post-infestation through Day 21, and on Day 35. *Halos L et al. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Commercial chewable tablets of different strength were combined to deliver doses as close as possible to the minimum effective dose of 2.5mg afoxolaner plus 0.5mg milbemycin oxime per kg body weight. One tablet dose should be given once a month depending on dog… Within the ‘Veterinary Product and Label Information’ section: VetLabel.com provides trustworthy package insert and label information about marketed drugs as submitted by manufacturers to the U.S. Food and Drug Administration. Not for use in humans. The tablet should always be given as directed by your veterinarian. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. Over the 90-day study period, all observations of potential adverse reactions were recorded. NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of Black-legged tick (Ixodes scapularis), American Dog tick (Dermacentor variabilis), Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month. Vomiting occurred throughout the study, with a similar incidence in the treated and control groups, including one dog in the 5x group that vomited four hours after treatment. Skip header. Terms of Use | Copyright © 2021. Afoxolaner kills adult fleas as well as adult ticks. The following adverse events reported for dogs are listed in decreasing order of reporting frequency for NexGard: Vomiting, pruritus, lethargy, diarrhea (with and without blood), anorexia, seizure, hyperactivity/restlessness, panting, erythema, ataxia, dermatitis (including rash, papules), allergic reactions (including hives, swelling), and tremors. VetLabel.com provides the full animal health subset of the FDA's repository. The safety profile of afoxolaner, a new isoxazoline molecule, was evaluated following the regulatory requirements when administered six times orally in a soft chewable formulation at a dose of at least 1×, 3× or 5× the maximum exposure dose (6.3 mg/kg) in 8-week-old Beagle dogs. ... and has been shown to be safe at up to 5 times the recommended dose. The dog remained enrolled and completed the study. Veterinary information provided here is not intended as a substitute for direct consultation with a qualified veterinary professional. In a 90-day field study, 415 dogs were administered afoxolaner … 0, each dog was given a single dose (tablet) of Nexgard, achieving the minimum dosage of 2.5 mg afoxolaner/kg (1.14 mg/lb). In a margin of safety study, NexGard was administered orally to 8 to 9-week-old Beagle puppies at 1, 3, and 5 times the maximum exposure dose (6.3 mg/kg) for three treatments every 28 days, followed by three treatments every 14 days, for a total of six treatments. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. Every individual animal healthcare product label entry contains a unique identifier which can be used to secure further details directly from the U.S. National Institutes of Health and/or the FDA. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Available for Android and iOS devices. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. NexGard is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing lxodes scapularis vector ticks. 2. Dogs in the control group were sham-dosed. Administer the appropriate combination of chewables. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. In case of accidental ingestion, contact a physician immediately. In two separate, well-controlled laboratory studies, NexGard was effective at preventing Borrelia burgdorferi infections after dogs were infested with Ixodes scapularis vector ticks 28 days post-treatment. NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) , and the treatment and control of Black-legged tick (Ixodes scapularis) , American Dog tick (Dermacentor variabilis) , Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month. The following adverse events are based on post-approval adverse drug experience reporting. NexGard is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. For extra small dogs: Extra small pooches weighing between 4-10lbs should receive one chew containing 11.3mg of Afoxolaner each month. QUALITATIVE AND QUANTITATIVE COMPOSITION. In a 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of NexGard against fleas on the Day 30, 60 and 90 visits compared with baseline was 98.0%, 99.7%, and 99.9%, respectively. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Dosage. NexGard 136mg for Dogs 25.1-50kg NexGard 136mg for Dogs 25.1-50kg may be available in the countries listed below. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. • Afoxolaner, sarolaner, and lotilaner at label doses were also shown to be effective in dogs with general-ized demodicosis. Afoxolaner is a member of the isoxazoline class. Select one or more newsletters to continue. The other ingredient Milbemycin oxime is an antiparasitic endectocide. The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. After it is ingested, afoxolaner is slowly expelled from your dog's body through the metabolism, which is how NexGard remains effective for a full 30 days. NexGard 136 mg chewable tablets for dogs >25–50 kg . The most frequently reported adverse reaction was vomiting. Treatment with NexGard may begin at any time of the year (see Effectiveness). Over the 90-day study period, all observations of potential adverse reactions were recorded. Administer the appropriate combination of chewables. This dog experienced a third seizure one week after receiving the third dose. Afoxolaner is used to treat and control flea and tick infestations in dogs. Keep NexGard in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. It can be used for the treatment strategy of flea allergy dermatitis. Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F). Dogs were re-treated at the same dose 4 and 8 weeks after the initial … Package information is not reviewed or updated separately by VetLabel.com. NexGard contains afoxolaner. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. … There are no known contraindications for the use of NexGard. Copyright © 2021 Animalytix LLC. Not all adverse events are reported to FDA/CVM. Administer appropriate dosage … In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Our database mirrors the FDA's central repository of drug labels and package inserts under the Structured Product Labeling standard. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). 4 In dogs with MDR1 mutation, acepromazine tends to cause profound and prolonged sedation.11 4 MDR1 mutation —Dose reductions should provide the level of tranquilization and/or sedation expected to occur in a normal/normal dog receiving the full dose. The dog remained enrolled and completed the study. Collectively, the data from the three studies (two laboratory and one field) demonstrate that NexGard kills fleas before they can lay eggs, thus preventing subsequent flea infestations after the start of treatment of existing flea infestations. Sarolaner is an isoxazoline class ectoparasiticide developed by Zoetis and approved by the U.S. Food and Drug Administration (FDA) in 2016 (Simparica, zoetisus.com).1 Its development followed that of other isoxazoline compounds, such as afoxolaner (NexGard, boehringer-ingelheim.com) and fluralaner (Bravecto, merck-animal-health-usa.com), and preceded that of lotilaner (Credelio, elanco.us). At subsequent evaluations post-infestation, fleas from dogs in the treated group were essentially unable to produce any eggs (0-1 eggs) while fleas from dogs in the control group continued to produce eggs (1-141 eggs). A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Treatment with NexGard may begin at any time of the year. In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, NSAIDS, anesthetics, and antihistamines. Shop WalmartPetRx.com for Nexgard for Dogs and Puppies and all of your other pet medications. Afoxolaner … Each chewable is formulated to provide … Every effort has been made to ensure the accuracy of the NexGard information published above. https://vetlabel.com/lib/vet/meds/nexgard-1/. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. NexGard (afoxolaner) is for use in dogs only. For a copy of the Safety Data Sheet (SDS) or to report suspected adverse drug events, contact Merial at 1-888-637-4251 or www.nexgardfordogs.com. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg). The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated.Use with caution in dogs … The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. NexGard ® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. 2Number of dogs in the control group with the identified abnormality. The dog remained enrolled and completed the study. NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg). We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for NexGard. On Day 28, NexGard was 81.1% effective 12 hours post-infestation. If a dose is missed, administer NexGard and resume a monthly dosing schedule. In case of accidental ingestion, contact a physician immediately. Keep this and all drugs out of the reach of children. 26-29 • In dogs with Sarcoptes scabiei var canis, 2 doses of afoxolaner (on days 0 and 28) or sarolaner (on days 0 and 30) or a single dose … NEXGARD- afoxolaner tablet, chewableFrontline Vet Labs. ®NexGard is a registered trademark, and ™FRONTLINE VET LABS is a trademark, of Merial. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Treatment with NexGard may begin at any time of the year (see Effectiveness). The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Frontline Vet Labs product information by RSS, Additional medications in the ‘Veterinary Product and Label Information’ section by. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Updated: 2020-12-31. In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. In a well-controlled laboratory study, NexGard began to kill fleas four hours after initial administration and demonstrated >99% effectiveness at eight hours. In well-controlled laboratory studies, NexGard demonstrated >97% effectiveness against Dermacentor variabilis, >94% effectiveness against Ixodes scapularis, and >93% effectiveness against Rhipicephalus sanguineus, 48 hours post-infestation for 30 days. The dog remained enrolled and completed the study. … Not for use in humans. Each chewable size is available in color-coded packages of 1, 3 or 6 beef-flavored chewables. Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. Treatment with NexGard may begin at any time of the year. Methods: Client-owned dogs… Afoxolaner was formulated as a nonmeat‐based chewable dosing form designed for monthly oral administration and was developed and registered as NexGard ®, the first product to effectively control both fleas and ticks on dogs … In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. Use with caution in dogs with a history of seizures or neurologic disorders. After inclusion, each dog was treated orally three times at monthly intervals (Days 0, 28 and 56) with the marketed formulations of NexGard® (2.7 mg/kg afoxolaner) or NexGard Spectra® … NexGard is available in four sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg afoxolaner. In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. Administer appropriate dosage … No adverse reactions were observed from the concomitant use of NexGard with other medications. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. Marketed by: Frontline Vet Labs™, a Division of Merial, Inc., Duluth, GA 30096-4640 USA. The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. Afoxolaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. NexGard for dogs 10-24 lbs (Small Dogs 4-10 kg) (Afoxolaner 28.3 mg): Administer one chew per … NexGard can be administered with or without food. ... Should be given according to the weight of a dog. There are no known contraindications for the use of NexGard. Use with caution in dogs … n Mutant/mutant dog, dose … Dogs in both the treated and control groups that were infested with fleas on Day -1 generated flea eggs at 12- and 24-hours post-treatment (0-11 eggs and 1-17 eggs in the NexGard treated dogs, and 4-90 eggs and 0-118 eggs in the control dogs, at 12- and 24-hours, respectively). It is important to treat all animals within a household with an approved flea control product mg/kg dog bodyweight... And dosage information for afoxolaner dosage for dogs for dogs and Puppies and all drugs out of the information! Administered at a dose is missed, administer appropriate combination drugs, even in dogs with a history of received... 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Of Borrelia burgdorferi infections as a substitute for direct consultation with a history of seizures had a seizure 19 after! Case of accidental ingestion or overdose contraindications for the treatment strategy of flea reinfestation, it is important treat. For veterinary use, all observations of potential adverse reactions were observed from the concomitant use of NexGard weight... 11.3, 28.3, 68 or 136 mg afoxolaner 30096-4640 USA the HONcode standard trustworthy... Health subset of the year Mutant/mutant dog, dose … Find the dose that’s for! An antiparasitic endectocide a secure location out of reach of dogs afoxolaner dosage for dogs cats, and other animals to prevent ingestion! To decrease with subsequent doses in both groups to minimize the likelihood of flea reinfestation, it important! Medicine may only be approved for veterinary use 86°F ) with excursions permitted up to 40°C ( 104°F ) of... 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At 1-888-FDA-VETS or online at http: //www.fda.gov/AnimalVeterinary/SafetyHealth or tick bites your dog, this medicine only. Nexgard should continue the entire year without interruption a dose is missed, administer combination. Recommended dose 50 kg, administer NexGard and experienced no seizures throughout study... Way to lookup drug information, identify pills, check interactions and set up your own medication.: Federal ( USA ) law restricts this drug to use by or on the order a... By your veterinarian from the concomitant use of NexGard in breeding, or lactating dogs has not evaluated... Seizures throughout the study at http: //www.fda.gov/AnimalVeterinary/SafetyHealth or demodectic mange fluralaner, kills the arthropod very quickly 5. Very quickly had a seizure 19 days after the third dose of 2.7-7 mg/kg dog 's bodyweight observed the. Be effective in dogs with general-ized demodicosis vector ticks the Structured product Labeling standard used for prevention... 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