Consult a physician. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. 0.03ppm; P=0.017). This chemical inventory is OSHA's premier one-stop shop for occupational chemical information. ethylene glycol was prepared by the Institute of Terrestrial Ecology, United Kingdom, based on the report Environmental hazard assessment: Ethylene glycol (Nielsen et al., 1993). 2-Butoxyethanol acetate is a colorless liquid with a fruity odor. CAS-Number. Ethylene Glycol Monoethyl Ether (110-80-5) LD50 oral rat 1746 mg/kg LD50 dermal rabbit … Ethylene Glycol Ethers Group - information sheet - Canada.ca Abbreviations for 2-butoxyethanol include EGBE and BE [1]. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. Diethylene Glycol Poisoning Precautions. 57, pp. Print Share on: Evidence. 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, butyl Oxitol, glycol butyl ether… A 2010 EPA re-evaluation found that ethylene glycol monobutyl ether is not likely to be carcinogenic to humans for exposures at or below reference concentrations or doses and in the absence of critical noncancer effects… 2-Butoxyethanol autoprotection is due to resiliance of newly formed erythrocytes to hemolysis. In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. Tyl RW, Millicovsky G, Dodd DE, Pritts IM, France KA, Fisher LC. The level of exposure depends upon the dose, duration, and work being done. Arch Toxicol. Find Lowest Prices. 4 Fukushima Medical University. Environ Health Perspect. 1987 Nov;91(2):222-34. NIOSH Criteria for a Recommended Standard. Int J Toxicol. Inhalation: Toxic ifinhaled. 2-BE itself is not commercially produced in Canada. It is also used in liquid soaps, cosmetics, industrial and household cleaners, and dry-cleaning compounds. It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. The ratings reflect potential health … Precautions. Information available on … Exposure to 60 ppm aerosolized ethylene glycol caused very noticeable irritation. … In humans, 100 ppm (69 mg/kg bw/day) resulted in ocular and respiratory Irritation, altered taste and nausea (Carpenter et al., 1956). The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. NLM The substance may cause effects on the central nervous system, blood, kidneys and liver. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Chemical Name. ICSC Short-Term Exposure. Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan. EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether ... toxicity data for EGBE and concluded that it can reasonably be anticipated to cause serious or irreversible chronic health effects in humans, specifically, liver toxicity and concerns for hematological effects. FIRST AID MEASURES First aid measures Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. 11.1. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Information on toxicological effects . Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: metabolism, disposition, and subchronic inhalation toxicity studies. Find Lowest Prices. Flammable and/or toxic … Ethylene … " DISCLAIMER: The ILO does not take responsibility for content presented on this web portal that is presented in any language other than English, which is the language used for the initial production and peer-review of original content. Pubmed Abstract Bauer P, Weber M, Mur JM, Protois JC, Bollaert PE, Condi A, Larcan A, Lambert H. Intensive Care Med. DIPROPYLENE GLYCOL BUTYL ETHER . This can cause anemia. USA.gov. Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. The RfD is an estimate (with uncertainty … 111-76-2], considering butoxyacetic acid in urine to characterise the internal exposure. -. Respiratory Effects: Inhaled ethylene glycol can irritate the respiratory tract. I. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. J Occup Health. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Substance name : Glycol Ether EB CAS-No. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate … (ethylene glycol monobutyl ether) [CAS No. Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. METHODS 53 Impregnation workers from two factories that make copper clad laminate with EGME as a solvent were recruited as the exposed group. In both the ethylene and diethylene glycol series, the relative rate of absorption declined from methyl to ethyl to butyl ether derivatives. 1988 Oct;43(1-3):5-21. doi: 10.1016/0378-4274(88)90017-3. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. 2-Butoxyethanol … Where is it found and how is it used? Ingestion or skin contact causes headache, nausea, vomiting, dizziness. It attacks some forms of plastics, rubber and coatings. Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. (USCG, 1999) Toxicol Appl Pharmacol. Reference Dose (RfD) for Chronic Oral Exposure . It is an ether-ester derivative. In this document, NIOSH recommends occupational exposure limits for ethylene glycol monobutyl ether (EGBE) and its acetate, ethylene glycol monobutyl ether acetate (EGBEA). I.A. Vapors irritate eyes and nose. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. HHS Please contact NTP, IARC, or EPAâs IRIS Hotline with questions on cancer and cancer classification. Health Hazard Assessments for Noncarcinogenic Effects . It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol… 4.3. Gaschromatographic determination of butoxyacetic acid after hydrolysis of conjugated metabolites in urine from workers exposed to 2-butoxyethanol. DIETHYLEN Glycol M-ETHYL ETHER Liquid. NIOSH Pocket Guide to ... in this product - not the product itself - compared to other product formulations. Symptoms may include tiredness, … The ether being relatively unreactive. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant ... 2 Japan Industrial Safety and Health Association. DIPROPYLENE GLYCOL BUTYL ETHER can be found in 39 products. | Environ Health Perspect. This site needs JavaScript to work properly. Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. | ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE For Synthesis Safety Data Sheet www.lobachemie.com 03/06/2016 3/8 4.2. 2-Methoxyethanol (McGregor et al., 1983), ethylene glycol monobutyl ether (Tyler, 1982), dlethylene glycol monobutyl ether (Thompson et al., 1984), dlethylene glycol dimethyl ether (McGregor et al., 1983), propylene glycol methyl ether {Mendrala, 1983c), and dlpropylene glycol methyl ether (Mendrala, 1983b) were negative 1n the cell culture test for unscheduled DNA synthesis. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. Occupational Exposure to Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate. It is liable to form peroxides on exposure to air and light. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. It is concluded that the available information continues to support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm. In the first study, a group of two men and six rats were exposed simultaneously for 4 hours to an EGBE concentration of 113 ppm in a 1,250 cubic ft room. 4 Fukushima Medical University. some . NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health Ethylene Glycol Monobutyl Ether (Laboratory) Revision Date 15-Dec-2015 Engineering … It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. Nagano K, Nakayama E, Oobayashi H, Nishizawa T, Okuda H, Yamazaki K. Environ Health Perspect. ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). 1983 May;68(3):405-14 During 2003, the production of EGBE in the European Union was approximately 161,000 tonnes. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. Animal studies have reported reproductive and developmental risks from inhalation … 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). 1984 Aug;57:75-84. doi: 10.1289/ehp.845775. Epub 2017 Jun 26. The main systemic adverse effects of 2-butoxyethanol are on the haematopoietic system (haemolytic effects), followed by possible teratogenic and testicular effects. Opinion on Ethylene glycol monobutyl ether _____ 7 3.1.9. | 1984 Aug;57:47-68. doi: 10.1289/ehp.845747. -, Toxicol Appl Pharmacol. Skin Contact Rinse with clear water Read More. OBJECTIVES To investigate the effects of ethylene glycol monomethyl ether (EGME) on haematology and reproduction in exposed workers. ICSC Routes of Exposure and Symptoms. Read More. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. : 111-76-2 Formula : C6H14O2 Synonyms : 2-butoxyethanol / BGE / butyl cellosolve / butyl OXITOL / butylglycol / butylglycol ether / EGBE / ethanol, 2-butoxy- / ethyleenglycolmonobutylether / ethylene glycol monobutyl ether / glycolmonobutylether / monobutyl ether … In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). Would you like email updates of new search results? Ethylene Glycol Monobutyl Ether; Community Right-To-Know Toxic Chemical Release Reporting, 60818-60825 [2015-25674] J Occup Health. Epub 2017 Jun 26. 1995;69(8):526-32. doi: 10.1007/s002040050207. The substance can be absorbed into the body by inhalation, through the skin and by ingestion. ETHYLENE OXIDE Causes reproductive effects . U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health… Likely routes of exposure : Inhalation; Skin and eye contact . US NIOSH Target Organs & Routes of Entry On the other hand, ethylene glycol, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monoacetate or ethylene glycol diacetate showed no such an effect. FIRST AID MEASURES First aid measures Eye contact Rinse … Transient non-cardiogenic pulmonary edema following massive ingestion of ethylene glycol butyl ether. 2-BE … The acute and subehronic toxicity of EGEE, EGPE and EGBE was reviewed by C. C. Conaway (Texaco, Note: Javascript is disabled or is not supported by your browser. Diethylene glycol ethers were absorbed more slowly than the corresponding ethylene glycol ethers. It is used as a solvent for lacquers, varnishes, enamels, and epoxy resins. 1992;18(4):250-1. doi: 10.1007/BF01709843. ETHYLENE GLYCOL ETHERS PANEL TO REMOVE ETHYLENE GLYCOL MONOBUTYL ETHER FROM THE TOXICS RELEASE INVENTORY UNDER SECTION 313 OF THE EMERGENCY PLANNING AND COMMUNITY RIGHT-TO-KNOW ACT OF 1986 Jonathon Busch Director, Ethylene Glycol …
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